Leveraging the Micellar Effect: Gold-Catalyzed Dehydrative Cyclizations in Water at Room Temperature
详细信息 查看全文
- 作者：Stefan R. K. Minkler ; Nicholas A. Isley ; Daniel J. Lippincott ; Norbert Krause ; Bruce H. Lipshutz
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：February 7, 2014
- 年：2014
- 卷：16
- 期：3
- 页码：724-726
- 全文大小：216K
- ISSN：1523-7052
文摘
The first examples of gold-catalyzed cyclizations of diols and triols to the corresponding hetero- or spirocycles in an aqueous medium are presented. These reactions take place within nanomicelles, where the hydrophobic effect is operating, thereby driving the dehydrations, notwithstanding the surrounding water. By the addition of simple salts such as sodium chloride, reaction times and catalyst loadings can be significantly decreased.