Cu-Catalyzed Asymmetric Conjugate Additions of Dialkyl- and Diarylzinc Reagents to Acyclic -Silyl- 详细信息    查看全文

• 作者：Monica A. Kacprzynski ; Stephanie A. Kazane ; Tricia L. May ; Amir H. Hoveyda
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：August 2, 2007
• 年：2007
• 卷：9
• 期：16
• 页码：3187 - 3190
• 全文大小：108K
• 年卷期：v.9,no.16(August 2, 2007)
• ISSN：1523-7052

文摘

A readily available and simple (MW = 444.5 g/mol) valine-based chiral phosphine is used to promote highly efficient catalytic asymmetricconjugate additions of dialkyl- and diarylzinc reagents to acyclic -silyl-,-unsaturated ketones. The catalytic asymmetric protocol allowsaccess to versatile allylsilanes that bear a trisubstituted olefin in high diastereo- and enantiomeric purity.