Synthesis of Ynone Trifluoroborates toward Functionalized Pyrazoles

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• 作者：James D. Kirkham ; Steven J. Edeson ; Stephen Stokes ; Joseph P. A. Harrity
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：October 19, 2012
• 年：2012
• 卷：14
• 期：20
• 页码：5354-5357
• 全文大小：234K
• 年卷期：v.14,no.20(October 19, 2012)
• ISSN：1523-7052

文摘

The synthesis of a range of novel ynone trifluoroborates has been achieved, in a two-pot process from propargylic alcohols. These alkynes have been subsequently used in the formation of a range of pyrazole trifluoroborate salts via cyclization with hydrazines. The products are generated with high levels of regiocontrol and in excellent yields and represent versatile synthetic intermediates.