Antimalarial Bromophycolides J−Q from the Fijian Red Alga Callophycus serratus
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- 作者：Amy L. Lane ; E. Paige Stout ; An-Shen Lin ; Jacques Prudhomme ; Karine Le Roch ; Craig R. Fairchild ; Scott G. Franzblau ; Mark E. Hay ; William Aalbersberg ; Julia Kubanek
- 刊名：Journal of Organic Chemistry
- 出版年：2009
- 出版时间：April 3, 2009
- 年：2009
- 卷：74
- 期：7
- 页码：2736-2742
- 全文大小：220K
- 年卷期：v.74,no.7(April 3, 2009)
- ISSN：1520-6904
文摘
Bromophycolides J−Q (1−8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene−benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9−18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.