Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells

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• 作者：Tapas R. Nayak ; Henrik Andersen ; Venkata S. Makam ; Clement Khaw ; Sukang Bae ; Xiangfan Xu ; Pui-Lai R. Ee ; Jong-Hyun Ahn ; Byung Hee Hong ; Giorgia Pastorin ; Barbaros Özyilmaz
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：June 28, 2011
• 年：2011
• 卷：5
• 期：6
• 页码：4670-4678
• 全文大小：1033K
• 年卷期：0
• ISSN：1936-086X

文摘

Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells’ proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene’s potential for stem cell research.