Total Synthesis of Denbinobin
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- 作者：Hsueh-Yun Lee ; Sunil Kumar ; Tzu-Cheng Lin ; Jing-Ping Liou
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：April 22, 2016
- 年：2016
- 卷：79
- 期：4
- 页码：1170-1173
- 全文大小：233K
- 年卷期：0
- ISSN：1520-6025
文摘
A total synthesis of denbinobin (1) in seven steps with an overall yield of 10% is reported. This synthesis used an FeCl3-assisted cyclization of stilbene to form a phenanthrene. The poor yields of the decarboxylation and methoxylation steps were improved upon to become essentially quantitative. This scalable methodology was carried out using ordinary laboratory reagents.