Orthogonal Control of Antibacterial Activity with Light

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• 作者：Willem A. Velema ; Jan Pieter van der Berg ; Wiktor Szymanski ; Arnold J. M. Driessen ; Ben L. Feringa
• 刊名：ACS Chemical Biology
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：9
• 期：9
• 页码：1969-1974
• 全文大小：340K
• ISSN：1554-8937

文摘

Selection of a single bacterial strain out of a mixture of microorganisms is of crucial importance in healthcare and microbiology research. Novel approaches that can externally control bacterial selection are a valuable addition to the microbiology toolbox. In this proof-of-concept, two complementary antibiotics are protected with photocleavable groups that can be orthogonally addressed with different wavelengths of light. This allows for the light-triggered selection of a single bacterial strain out of a mixture of multiple strains, by choosing the right wavelength. Further improvement toward additional orthogonally addressable antibiotics might ultimately lead to a novel methodology for bacterial selection in complex populations.