Malyngamide 2, an Oxidized Lipopeptide with Nitric Oxide Inhibiting Activity from a Papua New Guinea Marine Cyanobacterium

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• 作者：Karla L. Malloy ; Francisco A. Villa ; Niclas Engene ; Teatulohi Matainaho ; Lena Gerwick ; William H. Gerwick
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：January 28, 2011
• 年：2011
• 卷：74
• 期：1
• 页码：95-98
• 全文大小：126K
• 年卷期：v.74,no.1(January 28, 2011)
• ISSN：1520-6025

文摘

A Papua New Guinea collection of the marine cyanobacterium cf. Lyngbya sordida yielded three known compounds as well as a new PKS-NRPS-derived malyngamide with anti-inflammatory and cytotoxic activity. Malyngamide 2 features an extensively oxidized cyclohexanone ring. Resolution of the ring core as a 6,8,9-triol rather then a 7,8,9-triol and relative configuration was based on chemical shift and bond geometry modeling in conjunction with homonuclear and heteronuclear coupling constants, NOE and ROE correlations, and other structural information. Malyngamide 2 exhibited anti-inflammatory activity in LPS-induced RAW macrophage cells (IC₅₀ = 8.0 渭M) with only modest cytotoxicity to the mammalian cell line.