Padanamides A and B, Highly Modified Linear Tetrapeptides Produced in Culture by a Streptomyces sp. Isolated from a Marine Sediment
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- 作者：David. E. Williams ; Doralyn S. Dalisay ; Brian O. Patrick ; Teatulohi Matainaho ; Kerry Andrusiak ; Raamesh Deshpande ; Chad L. Myers ; Jeff S. Piotrowski ; Charles Boone ; Minoru Yoshida ; Raymond J. Andersen
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：August 5, 2011
- 年：2011
- 卷：13
- 期：15
- 页码：3936-3939
- 全文大小：734K
- 年卷期：v.13,no.15(August 5, 2011)
- ISSN：1523-7052
文摘
Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine sediment. Padanamide B is cytotoxic to Jurkat cells, and a chemical genomics analysis using Saccharomyces cerevisiae deletion mutants suggested that padanamide A inhibits cysteine and methionine biosynthesis or that these amino acids are involved in the yeast鈥檚 response to the peptide.