Myristicyclins A and B: Antimalarial Procyanidins from Horsfieldia spicata from Papua New Guinea
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- 作者：Zhenyu Lu ; Ryan M. Van Wagoner ; Cristopher D. Pond ; Ann R. Pole ; James B. Jensen ; D’Arbra Blankenship ; Brian T. Grimberg ; Robert Kiapranis ; Teatulohi K. Matainaho ; Louis R. Barrows ; Chris M. Ireland
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：January 17, 2014
- 年：2014
- 卷：16
- 期：2
- 页码：346-349
- 全文大小：197K
- ISSN：1523-7052
文摘
An antimalarial screen for plants collected from Papua New Guinea identified an extract of Horsfieldia spicata as having activity. Isolation of the active constituents led to the identification of two new compounds: myristicyclins A (1) and B (2). Both compounds are procyanidin-like congeners of myristinins lacking a pendant aromatic ring. Myristicyclin A was found to inhibit the ring, trophozoite, and schizont stages of Plasmodium falciparum at similar concentrations in the mid-渭M range.