Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp. nov.

详细信息    查看全文

• 作者：Karla L. Malloy ; Takashi L. Suyama ; Niclas Engene ; Hosana Debonsi ; Zhengyu Cao ; Teatulohi Matainaho ; Carmenza Spadafora ; Thomas F. Murray ; William H. Gerwick
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：January 27, 2012
• 年：2012
• 卷：75
• 期：1
• 页码：60-66
• 全文大小：324K
• 年卷期：v.75,no.1(January 27, 2012)
• ISSN：1520-6025

文摘

Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC₅₀ 4.0 渭M; 2, IC₅₀ 3.8 渭M).