Biosynthetically Intriguing Chlorinated Lipophilic Metabolites from Geographically Distant Tropical Marine Cyanobacteria
详细信息 查看全文
- 作者：Joshawna K. Nunnery ; Niclas Engene ; Tara Byrum ; Zhengyu Cao ; Sairam V. Jabba ; Alban R. Pereira ; Teatulohi Matainaho ; Thomas F. Murray ; William H. Gerwick
- 刊名：The Journal of Organic Chemistry
- 出版年：2012
- 出版时间：May 4, 2012
- 年：2012
- 卷：77
- 期：9
- 页码：4198-4208
- 全文大小：474K
- 年卷期：v.77,no.9(May 4, 2012)
- ISSN：1520-6904
文摘
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A鈥揅 and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Cura莽ao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.