First Natural Analogs of the Cytotoxic Thiodepsipeptide Thiocoraline A from a Marine Verrucosispora sp.

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• 作者：Thomas P. Wyche ; Yanpeng Hou ; Doug Braun ; Hannah C. Cohen ; May P. Xiong ; Tim S. Bugni
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：76
• 期：16
• 页码：6542-6547
• 全文大小：777K
• 年卷期：v.76,no.16(August 19, 2011)
• ISSN：1520-6904

文摘

A marine Verrucosispora sp. isolated from the sponge Chondrilla caribensis f. caribensis was found to produce thiocoraline, a potent cytotoxic compound. Five new analogs of thiocoraline were isolated and represent the first analogs of thiocoraline. 22鈥?Deoxythiocoraline (2), thiochondrilline C (5), and 12鈥?sulfoxythiocoraline (6) demonstrated significant cytotoxicity against the A549 human cancer cell line with EC₅₀ values of 0.13, 2.86, and 1.26 渭M, respectively. The analogs provide insight into the SAR and biosynthesis of thiocoraline. The DP4 probability method was used to analyze ab initio NMR calculations to confirm stereochemical assignments.