Myritonines A–C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton
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- 作者：Xiao-Hui Li ; Yu Zhang ; Jia-Hui Zhang ; Xiao-Nian Li ; Ming-Ming Cao ; Ying-Tong Di ; Zong-Gen Peng ; Jian-Dong Jiang ; Xiao-Jiang Hao
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：April 22, 2016
- 年：2016
- 卷：79
- 期：4
- 页码：1203-1207
- 全文大小：335K
- 年卷期：0
- ISSN：1520-6025
文摘
Myritonines A–C (1–3), three new alkaloids bearing an unprecedented heterohexacyclic skeleton, were isolated from Myrioneuron tonkinensis. Their structures were determined by a combination of spectroscopic data and single-crystal X-ray diffraction analysis. Compound 3 represents the first Myrioneuron alkaloid featuring a unique trans-decahydroquinoline motif and was also found to possess a rare cyano functionality. Compounds 1 and 2 showed inhibition against the hepatitis C virus in vitro.