Intercellular Carbon Nanotube Translocation Assessed by Flow Cytometry Imaging
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- 作者：Iris Marangon ; Nicole Boggetto ; C茅cilia M茅nard-Moyon ; Enrica Venturelli ; Marie-Lys B茅outis ; Christine P茅choux ; Nathalie Luciani ; Claire Wilhelm ; Alberto Bianco ; Florence Gazeau
- 刊名：Nano Letters
- 出版年：2012
- 出版时间：September 12, 2012
- 年：2012
- 卷：12
- 期：9
- 页码：4830-4837
- 全文大小：522K
- 年卷期：v.12,no.9(September 12, 2012)
- ISSN：1530-6992
文摘
The fate of carbon nanotubes in the organism is still controversial. Here, we propose a statistical high-throughput imaging method to localize and quantify functionalized multiwalled carbon nanotubes in cells. We give the first experimental evidence of an intercellular translocation of carbon nanotubes. This stress-induced longitudinal transfer of nanomaterials is mediated by cell-released microvesicles known as vectors for intercellular communication. This finding raises new critical issues for nanotoxicology, since carbon nanotubes could be disseminated by circulating extracellular cell-released vesicles and visiting several cells in the course of their passage into the organism.