Polyyne Hybrid Compounds from Notopterygium incisum with Peroxisome Proliferator-Activated Receptor Gamma Agonistic Effects
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- 作者：Xin Liu ; Olaf Kunert ; Martina Blunder ; Nanang Fakhrudin ; Stefan M. Noha ; Clemens Malainer ; Andreas Schinkovitz ; Elke H. Heiss ; Atanas G. Atanasov ; Manfred Kollroser ; Daniela Schuster ; Verena M. Dirsch ; Rudolf Bauer
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：November 26, 2014
- 年：2014
- 卷：77
- 期：11
- 页码：2513-2521
- 全文大小：377K
- ISSN：1520-6025
文摘
In the search for peroxisome proliferator-activated receptor gamma (PPAR纬) active constituents from the roots and rhizomes of Notopterygium incisum, 11 new polyacetylene derivatives (1鈥?b>11) were isolated. Their structures were elucidated by NMR and HRESIMS as new polyyne hybrid molecules of falcarindiol with sesquiterpenoid or phenylpropanoid moieties, named notoethers A鈥揌 (1鈥?b>8) and notoincisols A鈥揅 (9鈥?b>11), respectively. Notoincisol B (10) and notoincisol C (11) represent two new carbon skeletons. When tested for PPAR纬 activation in a luciferase reporter assay with HEK-293 cells, notoethers A鈥揅 (1鈥?b>3), notoincisol A (9), and notoincisol B (10) showed promising agonistic activity (EC50 values of 1.7 to 2.3 渭M). In addition, notoincisol A (9) exhibited inhibitory activity on NO production of stimulated RAW 264.7 macrophages.