Fully Orthogonally Protected 2-Deoxystreptamine from Kanamycin

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• 作者：M. Waqar Aslam ; Guuske F. Busscher ; David P. Weiner ; René ; de Gelder ; Floris P. J. T. Rutjes ; Floris L. van Delft
• 刊名：Journal of Organic Chemistry
• 出版年：2008
• 出版时间：July 4, 2008
• 年：2008
• 卷：73
• 期：13
• 页码：5131 - 5134
• 全文大小：188K
• 年卷期：v.73,no.13(July 4, 2008)
• ISSN：1520-6904

文摘

A fully orthogonally protected and enantiopure 2-deoxystreptamine derivative is prepared in a few straightforward steps from commercially available kanamycin. Resolution of a sterically hindered diacetate was effected by a Verenium esterase and was followed by a chemoselective Staudinger reduction−acylation protocol.