Rh(II)/Br酶nsted Acid Cocatalyzed Intramolecular Trapping of Ammonium Ylides with Enones: Diastereoselective Synthesis of 2,2,3-Trisubstituted Indolines

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• 作者：Liqin Jiang ; Renqi Xu ; Zhenghui Kang ; Yixiao Feng ; Fengxia Sun ; Wenhao Hu
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：September 5, 2014
• 年：2014
• 卷：79
• 期：17
• 页码：8440-8446
• 全文大小：384K
• ISSN：1520-6904

文摘

Highly diastereoselective intramolecular trapping of ammonium ylides with enones has been developed through a Rh(II)/Br酶nsted acid cocatalytic strategy. This process allows rapid and efficient construction of N-unprotected polyfunctional 2,2,3-trisubstituted indolines in moderate to good yields with excellent diastereoselectivity.