Remarkable 1,6-Acyclic Diastereoselection in the Coupling of a Novel Butadienyl Di-indium Compound with Aldehydes

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• 作者：Weishi Miao ; Wenshuo Lu ; and Tak Hang Chan
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：March 5, 2003
• 年：2003
• 卷：125
• 期：9
• 页码：2412 - 2413
• 全文大小：49K
• 年卷期：v.125,no.9(March 5, 2003)
• ISSN：1520-5126

文摘

The reaction between a novel butadienyl di-indium reagent and aldehydes showed remarkable 1,6-diastereoselectivity to give acetylenic diol products as a single diastereomer. A bicyclic transition state formed through intramolecular chelation control was proposed that might account for the high 1,6-diastereoselection result.