Electro-Thermal Vaporization Direct Analysis in Real Time-Mass Spectrometry for Water Contaminant Analysis during Space Missions

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• 作者：Prabha Dwivedi ; Daniel B. Gazda ; Joel D. Keelor ; Thomas F. Limero ; William T. Wallace ; Ariel V. Macatangay ; Facundo M. Fern谩ndez
• 刊名：Analytical Chemistry
• 出版年：2013
• 出版时间：October 15, 2013
• 年：2013
• 卷：85
• 期：20
• 页码：9898-9906
• 全文大小：372K
• 年卷期：v.85,no.20(October 15, 2013)
• ISSN：1520-6882

文摘

The development of a direct analysis in real time-mass spectrometry (DART-MS) method and first prototype vaporizer for the detection of low molecular weight (30鈥?00 Da) contaminants representative of those detected in water samples from the International Space Station is reported. A temperature-programmable, electro-thermal vaporizer (ETV) was designed, constructed, and evaluated as a sampling interface for DART-MS. The ETV facilitates analysis of water samples with minimum user intervention while maximizing analytical sensitivity and sample throughput. The integrated DART-ETV-MS methodology was evaluated in both positive and negative ion modes to (1) determine experimental conditions suitable for coupling DART with ETV as a sample inlet and ionization platform for time-of-flight MS, (2) to identify analyte response ions, (3) to determine the detection limit and dynamic range for target analyte measurement, and (4) to determine the reproducibility of measurements made with the method when using manual sample introduction into the vaporizer. Nitrogen was used as the DART working gas, and the target analytes chosen for the study were ethyl acetate, acetone, acetaldehyde, ethanol, ethylene glycol, dimethylsilanediol, formaldehyde, isopropanol, methanol, methylethyl ketone, methylsulfone, propylene glycol, and trimethylsilanol.