Effects of Cationic Hydroxyethyl Cellulose on Dyslipidemia in Hamsters
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- 作者：Shao-Ching Hung ; Wallace Yokoyama ; Hyunsook Kim ; Glenn Bartley ; William H.K. Anderson ; David R. Albers ; Marsha L. Langhorst ; David M. Williams ; William Stott ; Maciej Turowski ; Scott A. Young
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2012
- 出版时间：November 7, 2012
- 年：2012
- 卷：60
- 期：44
- 页码：11149-11156
- 全文大小：279K
- 年卷期：v.60,no.44(November 7, 2012)
- ISSN：1520-5118
文摘
Cationic hydroxyethyl cellulose (cHEC) was supplemented in a high-fat diet to determine if this new soluble fiber had an effect on hypercholesterolemia and dyslipidemia associated with cardiovascular disease using Golden Syrian hamster as an animal model. Supplementation of 3鈥?% cHEC in a high-fat diet for 4 weeks led to significant weight gain reduction in hamsters. In addition, significant decreases in adipose and liver weights, concentrations of plasma total, VLDL, and LDL cholesterol, and hepatic lipids were shown. No significant improvements in glucose and insulin levels were observed with cHEC; however, a significant increase in plasma adiponectin and a decrease in leptin were observed. As compared with controls, 8% cHEC-fed hamsters had greater levels of mRNA for CYP7A1 (cytochrome P450 7A1; 2-fold of control; P < 0.05), CYP51 (lanosterol 14伪-demethylase; 6-fold of control; P < 0.05), and LDLR (LDL receptor; 1.5-fold of control) in the liver. These findings suggest the possibility of the use of cHEC for cholesterol reduction and beneficial effects on the cardiovascular risk factors.