Functionalization of Platinum Complexes for Biomedical Applications

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• 作者：Xiaoyong Wang ; Xiaohui Wang ; Zijian Guo
• 刊名：Accounts of Chemical Research
• 出版年：2015
• 出版时间：September 15, 2015
• 年：2015
• 卷：48
• 期：9
• 页码：2622-2631
• 全文大小：526K
• ISSN：1520-4898

文摘

Platinum-based anticancer drugs are the mainstay of chemotherapy regimens in clinic. Nevertheless, the efficacy of platinum drugs is badly affected by serious systemic toxicities and drug resistance, and the pharmacokinetics of most platinum drugs is largely unknown. In recent years, a keen interest in functionalizing platinum complexes with bioactive molecules, targeting groups, photosensitizers, fluorophores, or nanomaterials has been sparked among chemical and biomedical researchers. The motivation for functionalization comes from some of the following demands: to improve the tumor selectivity or minimize the systemic toxicity of the drugs, to enhance the cellular accumulation of the drugs, to overcome the tumor resistance to the drugs, to visualize the drug molecules in vitro or in vivo, to achieve a synergistic anticancer effect between different therapeutic modalities, or to add extra functionality to the drugs.