Ligand-Free Copper-Catalyzed Regioselective C-2 Arylation of Imidazo[2,1-b]thiazoles

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• 作者：Guoli Huang ; Hongsheng Sun ; Xiaojie Qiu ; Can Jin ; Chen Lin ; Yingzhong Shen ; Juli Jiang ; Leyong Wang
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：October 7, 2011
• 年：2011
• 卷：13
• 期：19
• 页码：5224-5227
• 全文大小：740K
• 年卷期：v.13,no.19(October 7, 2011)
• ISSN：1523-7052

文摘

An effective, regioselective C-2 arylation of imidazo[2,1-b]thiazoles catalyzed by Cu(I) has been developed. This arylation proceeded smoothly without promotion of the ligands, and various functional (22 samples) groups were well tolerated. Preliminary mechanistic studies of this arylation are also reported.