Lycojaponicumins D and E: Two New Alkaloids from Lycopodium japonicum

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• 作者：Xiao-Jing Wang ; Yun-Bao Liu ; Li Li ; Shi-Shan Yu ; Hai-Ning Lv ; Shuang-Gang Ma ; Xiu-Qi Bao ; Dan Zhang ; Jing Qu ; Yong Li
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：November 16, 2012
• 年：2012
• 卷：14
• 期：22
• 页码：5688-5691
• 全文大小：275K
• 年卷期：v.14,no.22(November 16, 2012)
• ISSN：1523-7052

文摘

Two new alkaloids, lycojaponicumins D (1) and E (2), were isolated from the club moss Lycopodium japonicum. Their structures were elucidated by spectroscopic methods, calculated ECD, CD experiments and X-ray diffraction analysis. Lycojaponicumin D (1) possesses an unprecedented 5/7/6/6 tetracyclic skeleton formed by an unusual C3鈥揅13 linkage, which is first reported in Lycopodium alkaloids. The plausible biogenetic pathway of 1 is proposed.