Hydrogen-Bond-Activated Palladium-Catalyzed Allylic Alkylation via Allylic Alkyl Ethers: Challenging Leaving Groups

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• 作者：Xiaohong Huo ; Mao Quan ; Guoqiang Yang ; Xiaohu Zhao ; Delong Liu ; Yangang Liu ; Wanbin Zhang
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 21, 2014
• 年：2014
• 卷：16
• 期：6
• 页码：1570-1573
• 全文大小：298K
• 年卷期：v.16,no.6(March 21, 2014)
• ISSN：1523-7052

文摘

C鈥揙 bond cleavage of allylic alkyl ether was realized in a Pd-catalyzed hydrogen-bond-activated allylic alkylation using only alcohol solvents. This procedure does not require any additives and proceeds with high regioselectivity. The applicability of this transformation to a variety of functionalized allylic ether substrates was also investigated. Furthermore, this methodology can be easily extended to the asymmetric synthesis of enantiopure products (99% ee).