Macrolactonization of Peptide Thioesters Catalyzed by Imidazole and Its Application in the Synthesis of Kahalalide B and Analogues

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• 作者：Yangmei Li ; Marc Giulionatti ; Richard A. Houghten
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：12
• 期：10
• 页码：2250-2253
• 全文大小：139K
• 年卷期：v.12,no.10(May 21, 2010)
• ISSN：1523-7052

文摘

The macrolactonization of peptide thioester to yield cyclic depsipeptides was developed using imidazole as a catalyst. This strategy was applied to the synthesis of kahalalide B and its analogues.