Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.
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- 作者：Yasuhiro Igarashi ; Daisuke Asano ; Masashi Sawamura ; Yasuko In ; Toshimasa Ishida ; Masaya Imoto
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：April 1, 2016
- 年：2016
- 卷：18
- 期：7
- 页码：1658-1661
- 全文大小：237K
- ISSN：1523-7052
文摘
Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.