Monodispersed Polymeric Nanocapsules: Spontaneous Evolution and Morphology Transition from Reducible Hetero-PEG PICmicelles by Controlled Degradation

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• 作者：Wen-Fei Dong ; Akihiro Kishimura ; Yasutaka Anraku ; Sayan Chuanoi ; Kazunori Kataoka*
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：March 25, 2009
• 年：2009
• 卷：131
• 期：11
• 页码：3804-3805
• 全文大小：154K
• 年卷期：v.131,no.11(March 25, 2009)
• ISSN：1520-5126

文摘

In this communication, a novel “self-templating” strategy was used to prepare uniform and biocompatible nanocapsules by the addition of a reduction agent (i.e., DTT) into a solution of highly monodispersed PICmicelles bearing a heterodetachable PEG corona. PEG chains were released from PICmicelle shells following disulfide reduction which leads a spontaneous and drastic morphology evolution from micelles to vesicles induced by the decrease of the PEG weight fraction. Formation of uniform nanocapsules with controllable capsule size was achieved by careful control of the micelle composition and molecular weight of homo-P[Asp(DET)].