Experimental Measurement and Modeling of the Solubility of Biotin in Six Pure Solvents at Temperatures from 298.15 K to 333.85 K

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• 作者：Jiahui Su ; Chao Qian ; Nengzhen Luo ; Xiangao Xiang ; Yiming Xu ; Xinzhi Chen
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2014
• 出版时间：November 13, 2014
• 年：2014
• 卷：59
• 期：11
• 页码：3894-3899
• 全文大小：265K
• ISSN：1520-5134

文摘

The solubilities of biotin in water, methanol, ethanol, acetic acid, dimethylformamide (DMF), and dimethyl sulfoxide (DMSO) were measured at temperatures ranging from 298.15 K to 333.85 K (p = 0.1 MPa) by the synthetic method with a laser monitoring dynamic technique. The mole fraction solubilities of biotin were observed to be highest in DMSO, and be lowest in water. The experimental data were well-correlated with the modified Apelblat equation, van鈥檛 Hoff equation, and 位h equation, in which the correlation coefficients (R²) were noted in the range of 0.997 to 1.000 and the root-mean-square deviations (rmsd) were less than 2.82聽%. Thermodynamic studies showed that dissolution of biotin was an endothermic and spontaneous process in all selected solvents.