Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum

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• 作者：Jia-Yin Ding ; Chun-Mao Yuan ; Ming-Ming Cao ; Wei-Wei Liu ; Chun Yu ; Hai-Yuan Zhang ; Yu Zhang ; Ying-Tong Di ; Hong-Ping He ; Shun-Lin Li ; Xiao-Jiang Hao
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：August 22, 2014
• 年：2014
• 卷：77
• 期：8
• 页码：1800-1805
• 全文大小：304K
• ISSN：1520-6025

文摘

Seven new compounds, including a eupodienone-type lignan (1), a dibenzocyclooctadiene-type lignan (2), three tetrahydrofuran-type lignans (3鈥?b>5), and two 1-phenylbutyl benzoates (6, 7), together with six known compounds, were isolated from the mature carpels of Manglietiastrum sinicum. The structures of new compounds 1鈥?b>7 were defined by spectroscopic techniques, and the absolute configuration of manglisin A (1) was determined by X-ray crystallography. Compounds 1鈥?b>4 exhibited moderate antimicrobial activities (MIC values: 0.016鈥?.14 渭M) against Staphylococcus aureus, MRSA 82^#, MRSA 92^#, MRSA 98^#, and MRSA 331^#. Compounds 2 and 3 showed weak cytotoxic activity against five human tumor cell lines.