Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp3 C−H Bonds under Mild Reaction Conditions

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• 作者：Yiqing Feng ; Yuji Wang ; Bradley Landgraf ; Shi Liu ; Gong Chen
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：August 6, 2010
• 年：2010
• 卷：12
• 期：15
• 页码：3414-3417
• 全文大小：286K
• 年卷期：v.12,no.15(August 6, 2010)
• ISSN：1523-7052

文摘

A practical synthetic method for the annulation of benzo-rings by the intramolecular coupling of an aryl iodide and a methylene C−H bond is described. The palladium-catalyzed C−H functionalization is directed by an aminoquinoline carboxamide group, which can be easily installed and removed. High yields and broad substrate scope were achieved. An additive of ortho-phenyl benzoic acid, identified from a systematic screening, functions as a critical ligand for the catalytic process under mild condition, even at near room temperature.