Using Electron Paramagnetic Resonance Spectroscopy To Facilitate Problem Solving in Pharmaceutical Research and Development
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- 作者：Ian Mangion ; Yizhou Liu ; Mikhail Reibarkh ; R. Thomas Williamson ; Christopher J. Welch
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：August 19, 2016
- 年：2016
- 卷：81
- 期：16
- 页码：6937-6944
- 全文大小：530K
- 年卷期：0
- ISSN：1520-6904
文摘
As new chemical methodologies driven by single-electron chemistry emerge, process and analytical chemists must develop approaches to rapidly solve problems in this nontraditional arena. Electron paramagnetic resonance spectroscopy has been long known as a preferred technique for the study of paramagnetic species. However, it is only recently finding application in contemporary pharmaceutical development, both to study reactions and to track the presence of undesired impurities. Several case studies are presented here to illustrate its utility in modern pharmaceutical development efforts.