Glutathione-Responsive Polymeric Micelles Formed by a Biodegradable Amphiphilic Triblock Copolymer for Anticancer Drug Delivery and Controlled Release

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• 作者：Zhigang Xu ; Shiying Liu ; Yuejun Kang ; Mingfeng Wang
• 刊名：ACS Biomaterials Science & Engineering
• 出版年：2015
• 出版时间：July 13, 2015
• 年：2015
• 卷：1
• 期：7
• 页码：585-592
• 全文大小：507K
• ISSN：2373-9878

文摘

This article presents a novel glutathione (GSH)-responsive poly(ethylene glycol)-b-polycarbonate-b-poly(ethylene glycol) triblock copolymer that self-assembles into micellar nanoparticles and simutaneously carry hydrophobic anticancer drugs such as doxirubicin. These drug-loading micelles show glutathione-triggered decomposition that leads to controlled drug release and cytotoxicity to cancer cells. This polymeric drug-carrier system integrates features of facile synthesis, stimuli-responsive drug release, good biocompatibility, and relatively low toxicity of the dissociated segments, thus representing a promising anticancer drug carrier for potential clinical applications.