Ruthenium(II)-Catalyzed Regioselective Reductive Coupling of 伪-Imino Esters with Dienes

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• 作者：Shujie Zhu ; Xiaoxia Lu ; Yueting Luo ; Wei Zhang ; Huanfeng Jiang ; Ming Yan ; Wei Zeng
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 5, 2013
• 年：2013
• 卷：15
• 期：7
• 页码：1440-1443
• 全文大小：276K
• 年卷期：v.15,no.7(April 5, 2013)
• ISSN：1523-7052

文摘

A method for the highly regioselective reductive coupling reaction of N-aryl-伪-imino esters with dienes is described. The method utilizes the RuHCl(CO)(PPh₃)₃/iPrOH catalytic system under an Ar atmosphere and provides 伪-branched allylic 伪-amino acid derivatives. Application of this transformation to the concise synthesis of a natural plant growth regulator is demonstrated.