Resveratrol Oligomers from Vatica albiramis
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- 作者：Naohito Abe ; Tetsuro Ito ; Kenji Ohguchi ; Minori Nasu ; Yuichi Masuda ; Masayoshi Oyama ; Yoshinori Nozawa ; Masafumi Ito ; Munekazu Iinuma
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：September 24, 2010
- 年：2010
- 卷：73
- 期：9
- 页码：1499-1506
- 全文大小：334K
- 年卷期：v.73,no.9(September 24, 2010)
- ISSN：1520-6025
文摘
Five new stilbenoids, vatalbinosides A−E (1−5), and 13 known compounds (6−18) were isolated from the stem of Vatica albiramis. The effects of these new compounds on interleukin-1β-induced production of matrix metalloproteinase-1 (MMP-1) in human dermal fibroblasts were examined. Three resveratrol tetramers, (−)-hopeaphenol (6), vaticanol C (13), and stenophyllol C (14), were identified as strong inhibitors of MMP-1 production.