Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
详细信息 查看全文
- 作者：Wei Gao ; Hnin Y. Y. Nyein ; Ziba Shahpar ; Hossain M. Fahad ; Kevin Chen ; Sam Emaminejad ; Yuji Gao ; Li-Chia Tai ; Hiroki Ota ; Eric Wu ; James Bullock ; Yuping Zeng ; Der-Hsien Lien ; Ali Javey
- 刊名：ACS Sensor
- 出版年：2016
- 出版时间：July 22, 2016
- 年：2016
- 卷：1
- 期：7
- 页码：866-874
- 全文大小：724K
- ISSN：2379-3694
文摘
A flexible and wearable microsensor array is described for simultaneous multiplexed monitoring of heavy metals in human body fluids. Zn, Cd, Pb, Cu, and Hg ions are chosen as target analytes for detection via electrochemical square wave anodic stripping voltammetry (SWASV) on Au and Bi microelectrodes. The oxidation peaks of these metals are calibrated and compensated by incorporating a skin temperature sensor. High selectivity, repeatability, and flexibility of the sensor arrays are presented. Human sweat and urine samples are collected for heavy metal analysis, and measured results from the microsensors are validated through inductively coupled plasma mass spectrometry (ICP-MS). Real-time on-body evaluation of heavy metal (e.g., zinc and copper) levels in sweat of human subjects by cycling is performed to examine the change in concentrations with time. This platform is anticipated to provide insightful information about an individual’s health state such as heavy metal exposure and aid the related clinical investigations.