Enantioselective Synthesis of Axially Chiral Multifunctionalized Biaryls via Asymmetric Suzuki鈥揗iyaura Coupling

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• 作者：Yougui Zhou ; Shouliang Wang ; Wenhao Wu ; Qing Li ; Yuwei He ; Yue Zhuang ; Lanning Li ; Jiyan Pang ; Zhongyuan Zhou ; Liqin Qiu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：November 1, 2013
• 年：2013
• 卷：15
• 期：21
• 页码：5508-5511
• 全文大小：223K
• 年卷期：v.15,no.21(November 1, 2013)
• ISSN：1523-7052

文摘

Substituted 2-formylarylboronic acids were successfully employed as substrates for asymmetric Suzuki鈥揗iyaura coupling. By virtue of the coupling with dialkoxyphosphinyl substituted naphthyl bromides and 2-nitronaphthalen-1-yl triflouromethanesulfonate, a series of novel multifunctionalized axially chiral biaryls were prepared in 53鈥?7% yields with up to 97% ee using palladium-Cy-MOP as the catalyst. The methodology provides a highly efficient and practical strategy for the synthesis of novel multifunctionalized axially chiral biaryls.