Copper-Catalyzed C(sp2)鈥揌 Amidation with Azides as Amino Sources

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• 作者：Jiangling Peng ; Zeqiang Xie ; Ming Chen ; Jian Wang ; Qiang Zhu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：16
• 期：18
• 页码：4702-4705
• 全文大小：388K
• ISSN：1523-7052

文摘

A copper-catalyzed C鈥揌 amidation process, with azides as amino sources under oxidant-free conditions, has been developed. When N-heterocycles were employed as directing groups, sulfonylazide and benzoylazide could be used as amidating reagents to provide corresponding N-arylamides. When amidines or imine were used, tandem C鈥揘/N鈥揘 bond formation occurred to afford indazole derivatives in one pot.