Aspergillines A鈥揈, Highly Oxygenated Hexacyclic Indole鈥揟etrahydrofuran鈥揟etramic Acid Derivatives from Aspergillus versicolor
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- 作者：Min Zhou ; Ming-Ming Miao ; Gang Du ; Xiao-Nian Li ; Shan-Zhai Shang ; Wei Zhao ; Zhi-Hua Liu ; Guang-Yu Yang ; Chun-Tao Che ; Qiu-Fen Hu ; Xue-Mei Gao
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：October 3, 2014
- 年：2014
- 卷：16
- 期：19
- 页码：5016-5019
- 全文大小：278K
- ISSN：1523-7052
文摘
Aspergillines A鈥揈 (1鈥?b>5) are highly oxygenated cyclopiazonic acid (CPA)-derived alkaloids bearing a rigid and sterically congested hexacyclic indole鈥搕etrahydrofuran鈥搕etramate scaffold, isolated from the endophytic fungus Aspergillus vesicolor. Apergillines A鈥揅 represent a new subclass of CPA-derived alkaloids, and aspergillines B and E possess a butanoic acid methyl ester moiety. The structures, including absolute configuration, were elucidated by interpretation of the NMR, X-ray crystallographic, and circular dichroism data. All compounds displayed anti-TMV and cytotoxic activities.