文摘
Aspergillines A鈥揈 (1鈥?b>5) are highly oxygenated cyclopiazonic acid (CPA)-derived alkaloids bearing a rigid and sterically congested hexacyclic indole鈥搕etrahydrofuran鈥搕etramate scaffold, isolated from the endophytic fungus Aspergillus vesicolor. Apergillines A鈥揅 represent a new subclass of CPA-derived alkaloids, and aspergillines B and E possess a butanoic acid methyl ester moiety. The structures, including absolute configuration, were elucidated by interpretation of the NMR, X-ray crystallographic, and circular dichroism data. All compounds displayed anti-TMV and cytotoxic activities.