Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer Activity
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- 作者：Alexander G. Majouga ; Maria I. Zvereva ; Maria P. Rubtsova ; Dmitry A. Skvortsov ; Andrei V. Mironov ; Dulat M. Azhibek ; Olga O. Krasnovskaya ; Vasily M. Gerasimov ; Anna V. Udina ; Nikolay I. Vorozhtsov ; Elena K. Beloglazkina ; Leonid Agron ; Larisa V. Mikhina ; Alla V. Tretyakova ; Nikolay V. Zyk ; Nikolay S. Zefirov ; Alexander V. Kabanov ; Olga A. Dontsova
- 刊名：Journal of Medicinal Chemistry
- 出版年：2014
- 出版时间：July 24, 2014
- 年：2014
- 卷：57
- 期：14
- 页码：6252-6258
- 全文大小：299K
- ISSN：1520-4804
文摘
We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.