Synthesis of size-controllable Fe₃O₄ magnetic submicroparticles and its biocompatible evaluation in vitro

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• 作者：Qing-hua Tian 田庆华 ; Wen-bo Ning 宁文博 ; Wei-jia Wang 王惟嘉…
• 关键词：magnetite ; submicroparticles ; biocompatibility ; hemolysis ; cytotoxicity
• 刊名：Journal of Central South University
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：23
• 期：11
• 页码：2784-2791
• 全文大小：
• 刊物类别：Engineering
• 刊物主题：Engineering, general; Metallic Materials;
• 出版者：Central South University
• ISSN：2227-5223
• 卷排序：23

文摘

Large scaled uniform and size-controllable magnetic submicroparticles (MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe3+ and NaAc contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy (SEM), X-ray power diffraction (XRD) and vibrating sample magnetometer (VSM). The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe3+ and NaAc. In addition, the hemolysis and cytotoxicity of Fe₃O₄ MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT(3-(4,5-dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the interactions between MSPs and adhesive mouse fibroblast cell line(L929) were probed. Larger size of Fe₃O₄ MSPs demonstrates lower cell viability following an exposure to the cells.