Negative correlation of Nogo-A with the malignancy of oligodendroglial tumor
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- 作者：Nan-Xiang Xiong (1)
Hong-Yang Zhao (1)
Fang-Cheng Zhang (1)
Zhu-Qiang He (1) - 关键词：Nogo ; A ; oligodendroglial tumors ; immunohistochemistry ; R739.4 ; Nogo ; A ; 灏戠獊鑳惰川缁嗚優鑲跨槫 ; 鍏嶇柅缁勭粐鍖栧
- 刊名：Neuroscience Bulletin
- 出版年：2007
- 出版时间：January 2007
- 年：2007
- 卷：23
- 期：1
- 页码：41-45
- 全文大小：410KB
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Hong-Yang Zhao (1)
Fang-Cheng Zhang (1)
Zhu-Qiang He (1)
1. Department of Neurosurgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China - ISSN：1995-8218
文摘
Objective Nogo-A is an axon regeneration inhibitor, and its function in central nervous system (CNS) is still unknown. The present study is to explore the relationship between the expression of Nogo-A and the malignancy of oligodendroglial tumors in patients. Methods Tumor tissue samples with different malignancy grade were obtained from the hospitals. The samples used for detection had been diagnosed as oligodendroglial tumors (oligodendroglioma or anaplastic oligodendroglioma). The expression of Nogo-A was detected by immunohistochemistry and western-blot analysis. The correlation test between the Nogo-A expression and the morphological changes (the percentages of atypical cells and mitotic cells in the tumors) related to the malignancy of tumor tissues was performed. Results There was significant negative correlation between the Nogo-A expression and the morphological change of tumor tissues according to immunohistochemistry. Western-blot analysis also indicated that the gray value of Nogo-A protein band in the oligodendroglioma group was significantly higher than that in the anaplastic oligodendroglioma group. Conclusion Nogo-A expression was negatively correlated with the malignancy grade of oligodendroglial tumors.