Myricetin Facilitates Potassium Currents and Inhibits Neuronal Activity of PVN Neurons

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• 作者：ZeGang Ma (1) mazegang2000@163.com
  TianWei Liu (1)
• 关键词：Myricetin – ; Paraventricular nucleus – ; Potassium current
• 刊名：Neurochemical Research
• 出版年：2012
• 出版时间：July 2012
• 年：2012
• 卷：37
• 期：7
• 页码：1450-1456
• 全文大小：385.8 KB
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• 作者单位：1. Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, 266071 China
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Biochemistry
  Neurology
  
• 出版者：Springer Netherlands
• ISSN：1573-6903

文摘

The effects of myricetin on hypothalamic paraventricular nucleus (PVN) neurons in rats were investigated. By whole-cell patch clamp detection in hypothalamic brain slices, we showed that the action potential frequency in type-I PVN neurons dose-dependently decreased after myricetin treatment. Further studies demonstrated that myricetin may enhance potassium currents and shifts the voltage-dependence of activation of potassium currents to more negative potentials by 6.07 mV. Using calcium free/cadmium perfusion solution could reverse myricetin-induced enhancement of potassium currents in PVN neurons. These results suggested that inhibition of hypothalamic PVN neurons by myricetin might be attributed to the enhancement of potassium currents.