Colonizing while migrating: how do individual enteric neural crest cells behave?

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• 作者：Heather M Young (5)
  Annette J Bergner (5)
  Matthew J Simpson (6)
  Sonja J McKeown (5)
  Marlene M Hao (5)
  Colin R Anderson (5)
  Hideki Enomoto (5) (6)
  
  5. RIKEN Center for Developmental Biology ; Laboratory for Neuronal Differentiation and Regeneration ; Kobe ; Japan
  6. Division of Neural Differentiation and Regeneration ; Department of Physiology and Cell Biology ; Graduate School of Medicine ; Kobe University ; Kobe ; 650-0017 ; Japan
  
• 关键词：Collective cell migration ; Neural crest ; Directional migration ; Enteric nervous system
• 刊名：BMC Biology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：3,198 KB
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• 刊物主题：Life Sciences, general;
• 出版者：BioMed Central
• ISSN：1741-7007

文摘

Background Directed cell migration is essential for normal development. In most of the migratory cell populations that have been analyzed in detail to date, all of the cells migrate as a collective from one location to another. However, there are also migratory cell populations that must populate the areas through which they migrate, and thus some cells get left behind while others advance. Very little is known about how individual cells behave to achieve concomitant directional migration and population of the migratory route. We examined the behavior of enteric neural crest-derived cells (ENCCs), which must both advance caudally to reach the anal end and populate each gut region. Results The behavior of individual ENCCs was examined using live imaging and mice in which ENCCs express a photoconvertible protein. We show that individual ENCCs exhibit very variable directionalities and speed; as the migratory wavefront of ENCCs advances caudally, each gut region is populated primarily by some ENCCs migrating non-directionally. After populating each region, ENCCs remain migratory for at least 24 hours. Endothelin receptor type B (EDNRB) signaling is known to be essential for the normal advance of the ENCC population. We now show that perturbation of EDNRB principally affects individual ENCC speed rather than directionality. The trajectories of solitary ENCCs, which occur transiently at the wavefront, were consistent with an unbiased random walk and so cell-cell contact is essential for directional migration. ENCCs migrate in close association with neurites. We showed that although ENCCs often use neurites as substrates, ENCCs lead the way, neurites are not required for chain formation and neurite growth is more directional than the migration of ENCCs as a whole. Conclusions Each gut region is initially populated by sub-populations of ENCCs migrating non-directionally, rather than stopping. This might provide a mechanism for ensuring a uniform density of ENCCs along the growing gut.