Innate lymphoid cells, possible interaction with microbiota
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- 作者：Kazuyo Moro (1) (2) (3)
Shigeo Koyasu (1) (4)
1. Laboratory for Immune Cell Systems ; RIKEN Center for Integrative Medical Sciences (IMS) ; 1-7-22 Suehiro-cho ; Tsurumi-ku ; Yokohama ; 230-0045 ; Japan
2. Precursory Research for Embryonic Science and Technology (PRESTO) ; Japan Science and Technology Agency ; 7 Goban-cho ; Chiyoda-ku ; Tokyo ; 102-0076 ; Japan
3. Division of Immunobiology ; Department of Medical Life Science ; Graduate School of Medical Life Science ; Yokohama City University ; 1-7-29 Suehiro-cho ; Tsurumi-ku ; Yokohama ; 230-0045 ; Japan
4. Department of Microbiology and Immunology ; Keio University School of Medicine ; 35 Shinanomachi ; Shinjuku-ku ; Tokyo ; 160-8582 ; Japan - 关键词：ILC ; Epithelia ; Infection ; Homeostasis ; Allergy ; Inflammation ; Plasticity
- 刊名：Springer Seminars in Immunopathology
- 出版年：2015
- 出版时间：January 2015
- 年：2015
- 卷：37
- 期：1
- 页码：27-37
- 全文大小：906 KB
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- 刊物主题：Biomedicine
Immunology
Internal Medicine - 出版者：Springer Berlin / Heidelberg
- ISSN：1863-2300
文摘
Recent studies have identified novel lymphocyte subsets named innate lymphoid cells (ILCs) lacking antigen-specific receptors. ILCs are present in a wide variety of epithelial compartments and occupy an intermediate position between acquired immune cells and myeloid cells. ILCs are now classified into three groups: group 1 ILC, group 2 ILC, and group 3 ILC based on their cytokine production patterns that correspond to the helper T cell subsets Th1, Th2, and Th17, respectively. ILCs play important roles in protection against various invading microbes including multicellular parasites, and in the maintenance of homeostasis and repair of epithelial layers. Excessive activation of ILCs, however, leads to various inflammatory disease conditions. ILCs have thus attracted interests of many researchers in the fields of infectious immunity, inflammatory diseases, and allergic diseases. Because epithelial cells sense alterations in environmental cues, it is important to understand the functional interaction between epithelial cells, ILCs, and environmental factors such as commensal microbiota. We discuss in this review developmental pathways of ILCs, their functions, and contribution of commensal microbiota to the differentiation and function of ILCs.