Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways
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- 作者：Ya-feng Li ; Gayani Nanayakkara ; Yu Sun ; Xinyuan Li…
- 关键词：Caspase ; 1 ; Microarray datasets ; Meta ; analysis ; Inflammation and transcriptome
- 刊名：Journal of Hematology & Oncology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：6229KB
- 刊物主题：Oncology; Hematology; Cancer Research;
- 出版者：BioMed Central
- ISSN：1756-8722
- 卷排序：10
文摘
BackgroundIt is well established that caspase-1 exerts its biological activities through its downstream targets such as IL-1β, IL-18, and Sirt-1. The microarray datasets derived from various caspase-1 knockout tissues indicated that caspase-1 can significantly impact the transcriptome. However, it is not known whether all the effects exerted by caspase-1 on transcriptome are mediated only by its well-known substrates. Therefore, we hypothesized that the effects of caspase-1 on transcriptome may be partially independent from IL-1β, IL-18, and Sirt-1.