Calretinin-positive L5a pyramidal neurons in the development of the paralemniscal pathway in the barrel cortex

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• 作者：Junhua Liu (1)
  Bin Liu (1)
  XiaoYun Zhang (1)
  Baocong Yu (1)
  Wuqiang Guan (3)
  Kun Wang (1)
  Yang Yang (1)
  Yifan Gong (1)
  Xiaojing Wu (1)
  Yuchio Yanagawa (4)
  Shengxi Wu (5)
  Chunjie Zhao (1) (2)
  
  1. Key Laboratory of Developmental Genes and Human Diseases ; MOE ; Department of Anatomy and Neuroscience ; Medical School ; Southeast University ; Nanjing ; 210009 ; PR China
  3. Institute of Neurobiology ; Institutes of Brain Science and State Key Laboratory of Medical Neurobiology ; Fudan University ; Shanghai ; 200032 ; PR China
  4. Department of Genetic and Behavioral Neuroscience ; Gunma University Graduate School of Medicine ; 3-39-22 Showa-machi ; Maebashi ; 371-8511 ; Japan
  5. Department of Anatomy ; Histology and Embryology ; K.K. Leung Brain Research Centre ; School of Basic Medicine ; Fourth Military Medical University ; Xi鈥檃n ; 710032 ; PR China
  2. Center of Depression ; Beijing Institute for Brain Disorders ; Beijing ; 100069 ; PR China
  
• 关键词：Calretinin ; L5a pyramidal neuron ; Paralemniscal pathway ; Posterior medial nucleus ; Barrel cortex
• 刊名：Molecular Brain
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：7
• 期：1
• 全文大小：5,682 KB
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• 刊物主题：Neurosciences; Neurology;
• 出版者：BioMed Central
• ISSN：1756-6606

文摘

Background The rodent barrel cortex has been established as an ideal model for studying the development and plasticity of a neuronal circuit. The barrel cortex consists of barrel and septa columns, which receive various input signals through distinct pathways. The lemniscal pathway transmits whisker-specific signals to homologous barrel columns, and the paralemniscal pathway transmits multi-whisker signals to both barrel and septa columns. The integration of information from both lemniscal and paralemniscal pathways in the barrel cortex is critical for precise object recognition. As the main target of the posterior medial nucleus (POm) in the paralemniscal pathway, layer 5a (L5a) pyramidal neurons are involved in both barrel and septa circuits and are considered an important site of information integration. However, information on L5a neurons is very limited. This study aims to explore the cellular features of L5a neurons and to provide a morphological basis for studying their roles in the development of the paralemniscal pathway and in information integration. Results 1. We found that the calcium-binding protein calretinin (CR) is dynamically expressed in L5a excitatory pyramidal neurons of the barrel cortex, and L5a neurons form a unique serrated pattern similar to the distributions of their presynaptic POm axon terminals. 2. Infraorbital nerve transection disrupts this unique alignment, indicating that it is input dependent. 3. The formation of the L5a neuronal alignment develops synchronously with barrels, which suggests that the lemniscal and paralemniscal pathways may interact with each other to regulate pattern formation and refinement in the barrel cortex. 4. CR is specifically expressed in the paralemniscal pathway, and CR deletion disrupts the unique L5a neuronal pattern, which indicates that CR may be required for the development of the paralemniscal pathway. Conclusions Our results demonstrate that L5a neurons form a unique, input-dependent serrated alignment during the development of cortical barrels and that CR may play an important role in the development of the paralemniscal pathway. Our data provide a morphological basis for studying the role of L5a pyramidal neurons in information integration within the lemniscal and paralemniscal pathways.