MicroRNA-146a rs2910164 is associated with severe preeclampsia in Black South African women on HAART

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• 作者：Niren Ray Maharaj ; Prithiksha Ramkaran ; Siddharthiya Pillay…
• 关键词：miR ; 146a ; rs2910164 ; Preeclampsia ; HIV ; HAART ; Black SA women
• 刊名：BMC Genetics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：444KB
• 刊物主题：Life Sciences, general; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics; Genetics and Population Dynamics;
• 出版者：BioMed Central
• ISSN：1471-2156
• 卷排序：18

文摘

BackgroundSouth African (SA) Black women have a high prevalence of preeclampsia and HIV, both conditions associated with increased inflammation. miR-146a is an inflammatory-associated miR and a common single nucleotide polymorphism (rs2910164) has been associated with several disease conditions. To date, this SNP has not been investigated in SA Black women. We therefore aimed to investigate the miR-146a G > C SNP in SA Blacks with preeclampsia, and further examine possible association among preeclamptic (PE) women with HIV infection on HAART.