Evaluation of compatibility among artemether, pyrimethamine and sulphadoxine using analytical and isothermal calorimetry techniques

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• 作者：Sushma Gupta (1)
  Renu Chadha (1)
  
  1. University Institute of Pharmaceutical Sciences ; Panjab University ; Chandigarh ; 160014 ; India
  
• 关键词：Artemether ; Compatibility studies ; Drug interactions ; Combinations ; Calorimetry
• 刊名：Journal of Thermal Analysis and Calorimetry
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：120
• 期：1
• 页码：759-769
• 全文大小：1,897 KB
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  10. Seidlein, L, Bojang, K, Jones, P, Jaffar, S, Pinder, M, Obaro, S, Doherty, T, Haywood, M, Snounou, G, Gemperli, B, Gathmann, I, Royce, C, McAdam, K, Greenwood, B (1998) A randomized controlled trial of artemether/benflumetol, a new antimalarial and pyrimethamine/sulfadoxine in the treatment of uncomplicated falciparum malaria in African children. Am J Trop Med Hyg. 58: pp. 638-644
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Sciences
  Polymer Sciences
  Physical Chemistry
  Inorganic Chemistry
  Measurement Science and Instrumentation
  
• 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
• ISSN：1572-8943

文摘

The objective of the present study is to identify interactions and incompatibilities among antimalarial drugs in solid state and solution phase. The potential interactions can affect the chemical nature, the stability and bioavailability of drugs and, consequently, their therapeutic efficacy and safety. Herein, the incompatibility studies were performed on artemether: sulphadoxine/pyrimethamine and their physical and treated binary and ternary mixtures. DSC, FT-IR and PXRD outcomes showed no significant chemical changes in physical mixtures and treated samples with respect to their pure samples. In solid state, no changes in data output (exotherm) was observed during conducting tests in isothermal heat flow among binary and ternary mixtures. In solution phase, more exothermic value of excess energy by calorimetry indicated stronger interaction in ternary mixtures relative to binary mixtures. Current investigation unambiguously connoted that artemether was compatible with pyrimethamine or sulphadoxine in combinations, but their ternary mixtures are not safe if co-formulated.