参考文献:1. Whittemore, AS, Gong, G, John, EM, McGuire, V, Li, FP, Ostrow, KL (2004) Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites. Cancer Epidemiol Biomarkers Prev 13: pp. 2078-2083 2. Pal, T, Permuth-Wey, J, Betts, JA, Krischer, JP, Fiorica, J, Arango, H (2005) BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. Cancer 104: pp. 2807-2816 CrossRef 3. Claus, EB, Schildkraut, JM, Thompson, WD, Risch, NJ (1996) The genetic attributable risk of breast and ovarian cancer. Cancer 77: pp. 2318-2324 CrossRef 4. Srinivasan, M, Day, FC, Griffin, E, Tancredi, DJ, Burke, W, Pinsky, L (2011) Implementation outcomes of a multiinstitutional web-based ethical, legal, and social implications genetics curriculum for primary care residents in three specialties. Genet Med 13: pp. 553-562 CrossRef 5. Moyer VA. Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med. 2014;160(4). 6. Birch PH. Interactive e-counselling for genetics pre-test decisions: where are we now? Clin Genet. 2014. 7. Dhar, SU, Cooper, HP, Wang, T, Parks, B, Staggs, SA, Hilsenbeck, S (2011) Significant differences among physician specialties in management recommendations of BRCA1 mutation carriers. Breast Cancer Res Treat 129: pp. 221-227 CrossRef 8. Daly, MB, Axilbund, JE, Buys, S, Crawford, B, Farrell, CD, Friedman, S (2010) Genetic/familial high-risk assessment: breast and ovarian. J Natl Compr Cancer Netw 8: pp. 562-594 9. Pal, T, Cragun, D, Lewis, C, Doty, A, Rodriguez, M, Radford, C (2013) A statewide survey of practitioners to assess knowledge and clinical practices regarding hereditary breast and ovarian cancer. Genet Test Mol Biomark 17: pp. 367-375 CrossRef 10. Culver, JO, Bowen, DJ, Reynolds, SE, Pinsky, LE, Press, N, Burke, W (2009) Breast cancer risk communication: assessment of primary care physicians by standardized patients. Genet Med 11: pp. 735-741 CrossRef 11. Bellcross, CA, Kolor, K, Goddard, KA, Coates, RJ, Reyes, M, Khoury, MJ (2011) Awareness and utilization of BRCA1/2 testing among U.S. primary care physicians. Am J Prev Med 40: pp. 61-66 CrossRef 12. Baer, HJ, Brawarsky, P, Murray, MF, Haas, JS (2010) Familial risk of cancer and knowledge and use of genetic testing. J Gen Intern Med 25: pp. 717-724 CrossRef 13. Olaya, W, Esquivel, P, Wong, JH, Morgan, JW, Freeberg, A, Roy-Chowdhury, S (2009) Disparities in BRCA testing: when insurance coverage is not a barrier. Am J Surg 198: pp. 562-565 CrossRef 14. Quillin, JM, Krist, AH, Gyure, M, Corona, R, Rodriguez, V, Borzelleca, J (2014) Patient-reported hereditary breast and ovarian cancer in a primary care practice. J Community Genet 5: pp. 179-183 CrossRef 15. Thompson, HS, Sussner, K, Schwartz, MD, Edwards, T, Forman, A, Jandorf, L (2012) Receipt of genetic counseling recommendations among black women at high risk for BRCA mutations. Genet Test Mol Biomark 16: pp. 1257-1262 CrossRef 16. Bellcross, CA, Leadbetter, S, Alford, SH, Peipins, LA (2013) Prevalence and healthcare actions of women in a large health system with a family history meeting the 2005 USPSTF recommendation for BRCA genetic counseling referral. Cancer Epidemiol Biomarkers Prev 22: pp. 728-735 CrossRef 17. Stuckey A, Febbraro T, Laprise J, Wilbur JS, Lopes V, Robison K. Adherence patterns to National Comprehensive Cancer Network Guidelines for referral of women with breast cancer to genetics professionals. Am J Clin Oncol. 2014. 18. Trivers, KF, Baldwin, LM, Miller, JW, Matthews, B, Andrilla, CH, Lishner, DM (2011) Reported referral for genetic counseling or BRCA 1/2 testing among United States physicians: a vignette-based study. Cancer 117: pp. 5334-5343 CrossRef 19. Appleton, S, Watson, M, Rush, R, Garcia-Minaur, S, Porteous, M, Campbell, J (2004) A randomised controlled trial of a psychoeducational intervention for women at increased risk of breast cancer. Br J Cancer 90: pp. 41-47 CrossRef 20. Cull, A, Miller, H, Porterfield, T, Mackay, J, Anderson, ED, Steel, CM (1998) The use of videotaped information in cancer genetic counselling: a randomized evaluation study. Br J Cancer 77: pp. 830-837 CrossRef 21. Mancini, J, Nogu猫s, C, Adenis, C, Berthet, P, Bonadona, V, Chompret, A (2006) Impact of an information booklet on satisfaction and decision-making about BRCA genetic testing. Eur J Cancer 42: pp. 871-881 CrossRef 22. Schwartz, MD, Benkendorf, J, Lerman, C, Isaacs, C, Ryan-Robertson, A, Johnson, L (2001) Impact of educational print materials on knowledge, attitudes, and interest in BRCA1/BRCA2: testing among Ashkenazi Jewish women. Cancer 92: pp. 932-940 CrossRef 23. Skinner, CS, Schildkraut, JM, Berry, D, Calingaert, B, Marcom, PK, Sugarman, J (2002) Pre-counseling education materials for BRCA testing: does tailoring make a difference?. Genet Test 6: pp. 93-105 CrossRef 24. Roosmalen, MS, Stalmeier, PF, Verhoef, LC, Hoekstra-Weebers, JE, Oosterwijk, JC, Hoogerbrugge, N (2004) Randomised trial of a decision aid and its timing for women being tested for a BRCA1/2 mutation. Br J Cancer 90: pp. 333-342 CrossRef 25. Wolfe CR, Reyna VF, Widmer CL, Cedillos EM, Fisher CR, Brust-Renck PG, et al. Efficacy of a web-based intelligent tutoring system for communicating genetic risk of breast cancer: a fuzzy-trace theory approach. Med Decis Making. 2014. 26. Rupert, DJ, Squiers, LB, Renaud, JM, Whitehead, NS, Osborn, RJ, Furberg, RD (2013) Communicating risk of hereditary breast and ovarian cancer with an interactive decision support tool. Patient Educ Couns 92: pp. 188-196 CrossRef 27. Burke, W, Culver, J, Pinsky, L, Hall, S, Reynolds, SE, Yasui, Y (2009) Genetic assessment of breast cancer risk in primary care practice. Am J Med Genet A 149A: pp. 349-356 CrossRef 28. Collins, FS, McInerney, JD (2007) Core competencies in genetics for health professionals. National Coalition for Health Professional Education in Genetics, Lutherville, MD 29. Burke, W, Emery, J (2002) Genetics education for primary-care providers. Nat Rev Genet 3: pp. 561-566 CrossRef ACOG Practice Bulletin No. 103: hereditary breast and ovarian cancer syndrome. Obstet Gynecol 113: pp. 957-966 CrossRef 30. Anderson, JA, Weitz, JI (2010) Hypercoagulable states. Clin Chest Med 31: pp. 659-673 CrossRef 31. Dungan, JS (2010) Carrier screening for cystic fibrosis. Obstet Gynecol Clin N Am 37: pp. 47-59 CrossRef 32. Fowler, FJ, Levin, CA, Sepucha, KR (2011) Informing and involving patients to improve the quality of medical decisions. Health Aff (Millwood) 30: pp. 699-706 CrossRef 33. Guttmacher, AE, Collins, FS (2002) Genomic medicine鈥揳 primer. N Engl J Med 347: pp. 1512-1520 CrossRef 34. Martin, JR, Wilikofsky, AS (2004) Genetic counseling in primary care: longitudinal, psychosocial issues in genetic diagnosis and counseling. Prim Care 31: pp. 509-524 CrossRef 35. National Cancer Institute. 2010; Pages. Accessed at National Cancer Institute at http://www.cancer.gov/cancertopics/pdq/genetics/risk-assessment-and-counseling/HealthProfessional/ on November 5, 2014 36. Novak, MJ, Tabrizi, SJ (2010) Huntington's disease. BMJ 340: pp. c3109 CrossRef 37. Sokol, DK (2006) Truth-telling in the doctor鈥損atient relationship: a case analysis. Clin Ethics 1: pp. 1-5 CrossRef 38. National Coalition for Health Professional Education in Genetics. Core competencies for all health professionals. 3rd ed. Lutherville, MD: NCHPEG; 2007. http://www.nchpeg.org/index.php?option=com_content&view=article&id=237&Itemid=84. 39. Amir, E, Freedman, OC, Seruga, B, Evans, DG (2010) Assessing women at high risk of breast cancer: a review of risk assessment models. J Natl Cancer Inst 102: pp. 680-691 CrossRef 40. Hoffman, RM, Lewis, CL, Pignone, MP, Couper, MP, Barry, MJ, Elmore, JG (2010) Decision-making processes for breast, colorectal, and prostate cancer screening: the DECISIONS survey. Med Dec Making 30: pp. 53S-64S CrossRef 41. Cukier, YR, Thompson, HS, Sussner, K, Forman, A, Jandorf, L, Edwards, T (2013) Factors associated with psychological distress among women of African descent at high risk for BRCA mutations. J Genet Couns 22: pp. 101-107 CrossRef 42. Jabaley Leonarczyk T, Mawn BE. Cancer risk management decision making for BRCA鈥?鈥墂omen. West J Nurs Res. 2014. 43. Kegelaers, D, Merckx, W, Odeurs, P, Ende, J, Blaumeiser, B (2014) Disclosure pattern and follow-up after the molecular diagnosis of BRCA/CHEK2 mutations. J Genet Couns 23: pp. 254-261 CrossRef 44. Vadaparampil, ST, Malo, T, Cruz, C, Christie, J (2012) Do breast cancer patients tested in the oncology care setting share BRCA mutation results with family members and health care providers?. J Cancer Epidemiol 2012: pp. 498062 CrossRef 45. Green, MJ, Biesecker, BB, McInerney, AM, Mauger, D, Fost, N (2001) An interactive computer program can effectively educate patients about genetic testing for breast cancer susceptibility. Am J Med Genet 103: pp. 16-23 CrossRef 46. Green, MJ, Peterson, SK, Baker, MW, Harper, GR, Friedman, LC, Rubinstein, WS (2004) Effect of a computer-based decision aid on knowledge, perceptions, and intentions about genetic testing for breast cancer susceptibility: a randomized controlled trial. JAMA 292: pp. 442-452 CrossRef 47. Ozuah, PO, Reznik, M (2007) Residents鈥?asthma communication skills in announced versus unannounced standardized patient exercises. Ambul Pediatr 7: pp. 445-448 CrossRef